Epilepsy in Dogs: Many Vets Skip Key Drug Monitoring

A survey of 187 veterinarians found that one-third did not routinely check anti-seizure drug levels in the blood of epileptic dogs, suggesting significant gaps in long-term monitoring practices.

Journal: Frontiers in Veterinary Science
Sample Size: 187 veterinarians in phase I; 36 in phase II
Study Type: Prospective two-phase survey study
Published: 2026-07-21
Species:

Key Findings

  • One-third of veterinarians did not routinely measure antiseizure-drug blood concentrations.
  • Long-term monitoring was identified as a challenging aspect of epilepsy management.

A Common Condition That Needs More Than Just Counting Seizures

If your dog has epilepsy, you already know how stressful it can be. Watching for seizures, managing daily medication, and keeping track of symptoms takes real effort. But a new survey published in Frontiers in Veterinary Science suggests there may be a gap in how epilepsy in dogs gets managed over the long term — and it’s one that could affect your dog’s care.

The survey found that one in three veterinarians did not routinely check anti-seizure drug levels in their epileptic patients’ blood. That’s a significant finding, because knowing whether a medication is at the right level is a key part of keeping seizures under control safely.

Why Drug Levels in the Blood Matter So Much

Anti-seizure medications — drugs like phenobarbital or potassium bromide — work best when they stay within a certain range in the bloodstream. Think of it like adjusting a thermostat: too low, and the drug won’t stop seizures effectively. Too high, and it can cause serious side effects, including damage to the liver or kidneys over time.

Checking blood levels is how vets know if the “thermostat” is set correctly. It’s not something you can judge just by counting seizures. A dog might be seizure-free but still have dangerously high drug levels building up silently in the body.

What the Study Found

Researchers surveyed veterinarians in two phases — 187 in the first phase and 36 in the second — about how they managed canine epilepsy over the long term.

The results pointed to a clear problem:

  • One-third of vets did not routinely measure anti-seizure drug concentrations in their epileptic canine patients’ blood.
  • Veterinarians identified long-term monitoring as one of the hardest parts of managing epilepsy in dogs.

This wasn’t about bad intentions. The study suggests the challenge is systemic — long-term epilepsy care is complex, and consistent monitoring protocols are not uniformly in place across veterinary practices.

What Good Epilepsy Monitoring Looks Like

So what should you expect if your dog has epilepsy? The study’s findings point to a standard of care that goes beyond just watching for seizures. According to the research context, dogs on anti-seizure medications should ideally receive:

  • Regular blood tests to check drug levels and organ health (especially the liver and kidneys)
  • Drug concentration checks when starting a new medication, changing a dose, or if seizures worsen
  • Structured follow-up visits on a schedule, not just when something seems wrong

This kind of proactive monitoring helps catch problems early — before a side effect becomes serious or a sub-therapeutic dose allows seizures to escalate.

What This Means If Your Dog Has Epilepsy

This study is a reminder that you are your dog’s most important advocate. If your dog is on anti-seizure medication and you haven’t had a conversation with your vet about regular blood monitoring, it’s time to bring it up.

Not all practices have standardized protocols for this. That doesn’t make your vet negligent — it reflects a real gap in how these cases are handled across the board. But knowing about the gap means you can ask the right questions.

Here’s what you can do right now:

  • Ask your vet: “How often should we check [medication name] blood levels?”
  • Request a schedule: Find out how frequently liver and kidney panels are recommended for your dog’s specific medication.
  • Keep a seizure diary: Tracking frequency, duration, and severity helps your vet spot trends that bloodwork alone might miss.
  • Don’t skip follow-up appointments, even when things seem stable. Drug levels can drift over time without obvious symptoms.

Talking to Your Vet About a Monitoring Plan

If your dog was recently diagnosed with epilepsy, or if you’re not sure whether your current vet has a long-term monitoring plan in place, consider asking these specific questions at your next visit:

  • “When should we do the first blood level check after starting this medication?”
  • “What signs should prompt me to call sooner rather than waiting for the next scheduled visit?”
  • “Are there any organ function tests I should know about for this medication?”

Most vets welcome these questions. They signal that you’re an engaged owner who wants to stay on top of your dog’s care.

Limitations of This Research

This study was based on a survey, which means it captures what vets report doing — not necessarily what actually happens in every clinic. There is also the possibility of self-selection bias, meaning the vets who responded may not perfectly represent all practices everywhere.

Still, a finding that one-third of surveyed vets skipped routine drug monitoring is striking. It points to a real need for clearer guidelines and better support for long-term epilepsy management across veterinary medicine.

The Bottom Line

Epilepsy in dogs is a manageable condition — but managing it well takes more than just seizure counts. A new survey suggests that many dogs on anti-seizure drugs may not be getting the routine blood monitoring they need to stay safe. If your dog has epilepsy, talk to your vet about building a structured monitoring plan. Regular drug level checks and organ panels aren’t optional extras — they’re a core part of keeping your dog healthy for the long haul.


This article summarizes peer-reviewed research for educational purposes. Always consult with your veterinarian for personalized advice about your pet’s health and behavior.

Reference

Dog Epilepsy Care Often Falls Short on Long-Term Drug Monitoring. (2026). Frontiers in Veterinary Science. DOI: https://doi.org/10.3389/fvets.2026.1868929