The benefit
The good news is that giving your dog a treat containing cannabidiol (CBD), L-tryptophan, and α-casozepine before a stressful event led to a smaller increase in their stress hormone levels. Dogs showed a mild physiological benefit, with their cortisol spike reduced during a car ride stress scenario. Calming effects were modest overall, but no adverse reactions were observed at either tested dose. For dogs facing mild stress, these chews may help take the edge off without causing side effects.
The science
CBD interacts with your dog’s endocannabinoid system, which helps regulate mood and stress responses. L-tryptophan is an amino acid that supports serotonin production, a neurotransmitter linked to calmness and well-being. α-Casozepine, a milk protein-derived peptide, is thought to have gentle anxiolytic (anxiety-lowering) effects. Together, these ingredients target the hormonal pathway that triggers cortisol release, blunting the body’s acute stress response. By lowering the physiological stress marker, this combination can offer support when your dog faces stressful but routine situations like car rides.
What the study found
Results showed dogs receiving the CBD-combination chew had a statistically smaller rise in cortisol during the car ride stress test compared to those given a placebo. This means their bodies produced less of the primary stress hormone in response to the challenge. Overall anxiety behaviors, such as restlessness, panting, or vocalizing, did not significantly differ between groups. In plain terms, you may not see dramatic changes in your dog’s outward behavior immediately. Heart rate measurements stayed similar in both groups, suggesting cardiovascular stress wasn’t notably reduced. No adverse effects were noted from either 2 mg/kg or 4 mg/kg CBD doses. Practically, this suggests safety at these levels for most dogs. The blunted hormone spike supports a modest physiological benefit, even if visible signs of calmness are limited. For dogs with mild anxiety, this internal stress reduction could help them recover faster after a stressful event.
Real-world application
At home: If your dog gets anxious before car rides, thunder, or fireworks, a CBD-combination treat may help them handle the experience with less internal stress. You might notice your dog settles a little sooner after the event. For example, a young border collie who usually trembles in traffic could show less shaking, even if she still pants. An older terrier who whines during storms might rest more comfortably afterward, even if he barks at the thunder. These treats work best for mild stress, not severe phobias. Use them alongside positive training or comfort routines for the best results.
With your veterinarian: If your dog has ongoing anxiety or you’re not sure about dosing, bring up calming chews during your next checkup. Your vet can help you choose a safe product and recommend the right dose for your dog’s weight and health status. For dogs with more intense fears, your vet may suggest combining chews with behavior modification or prescription medications. Always trial any new supplement in a relaxed setting before a stressful event.
How to implement
- Choose a CBD-combination treat labeled with L-tryptophan and α-casozepine for dogs, checking dosing instructions carefully.
- Give the treat 30–60 minutes before your dog’s anticipated stressor, such as a car ride or thunderstorm.
- Start with the lowest recommended dose for your dog’s weight, and observe for any digestive upset or changes.
- Use a low-stress scenario as a test run—try the treat before a short drive rather than a long trip.
- Monitor your dog’s behavior and recovery after the stressor, noting any changes in restlessness or ability to settle.
- Pair the treat with a comfort routine: favorite toy, cozy blanket, or gentle petting during the stressful event.
- If your dog tolerates the supplement well, you can use it for future mild stressors.
- Keep your veterinarian informed about supplement use, especially if your dog is on other medications or has health conditions.
What to expect
Within the first use, your dog’s cortisol response may be lower during the stressful event. You may notice a subtle shift, such as quicker recovery or less trembling after the car ride. Visible changes in behavior—like reduced panting or vocalizing—are likely to be minor and may not show up right away. Some dogs respond best after several uses, while others show little change in outward signs but still benefit internally. Most dogs tolerate the treat without problems from the start. For lasting results, combine with comfort routines and monitor for gradual improvements over a few exposures.
Potential concerns
- Dogs with severe anxiety or phobias may need additional interventions beyond calming treats—consult your veterinarian for a tailored plan.
- Digestive sensitivity or food allergies require checking ingredient lists before offering any new supplement.
- Dogs on prescription medications should have supplement use reviewed by a veterinarian to avoid interactions.
- For dogs with chronic medical conditions, trial the treat in a calm setting and monitor closely for unexpected reactions.
- Puppies under six months or pregnant dogs should only use calming supplements under veterinary guidance.
Study limitations
- Blinded crossover trial included 54 pet dogs exposed to a car-ride stress scenario.
- Only acute, single-dose effects measured; long-term outcomes are unknown.
- Hormonal and behavioral effects assessed during car travel, not other stressors.
- Individual variation in response not fully characterized.
- No reported data on breed, age, or underlying health conditions of participating dogs.
Bottom line
CBD-combination calming treats can modestly reduce stress hormone spikes in mildly anxious dogs without causing side effects. You can try these treats before routine stressors—just check dosing and use alongside comfort strategies.
Your implementation checklist
Gather a CBD-combination treat formulated for dogs that lists L-tryptophan and α-casozepine as active ingredients, and check the dosing chart for your dog’s weight. About an hour before your next car trip or expected thunderstorm, offer the treat, then let your dog relax with their favorite blanket or toy. Start with a short drive or a mild stressor so you can watch for any reactions and note changes in how your dog settles after the event. If your dog seems comfortable and shows no digestive upset, continue using the treat for future mild stressors, like visits to the groomer or noisy celebrations. Keep a log of your dog’s stress signs and recovery each time. Share these observations with your veterinarian, especially if your dog’s anxiety is persistent or severe, so you can adjust your approach as needed.
Disclaimer
This brief is for educational purposes only and does not replace professional veterinary advice. Always consult your veterinarian before starting any new supplement or behavioral intervention for your dog.
