Magnesium Improves Kidney Stress Markers in Cats with Early CKD

Study finds magnesium supplement lowered serum phosphorus in cats.

Journal: Journal of Veterinary Internal Medicine
Sample Size: 31 cats with early CKD
Study Type: Double-blind randomized controlled trial
Published: 2025
Species:

Key Findings

  • Magnesium supplement lowered serum phosphorus
  • FGF-23 significantly reduced vs. placebo
  • Calcium remained more stable (fewer hypercalcemia cases)
  • No adverse effects reported
  • Potential to slow CKD progression markers

Magnesium Supplements May Help Cats With Early Kidney Disease: New Study Insights

If your cat has been diagnosed with early kidney disease, you’re not alone in feeling a bit overwhelmed by all the new information and choices. Imagine Sarah, who just learned that her 12-year-old tabby, Milo, has early-stage kidney issues—she wonders if there’s anything more she can do beyond just switching foods. This new study offers some hopeful news: magnesium supplements may help slow kidney stress in cats, giving you another option to discuss with your vet.

You’ll learn how magnesium might support your cat’s kidneys, what the research found, and practical steps you can try—so you feel confident helping your cat live well.

Research Background

Kidney disease (CKD) is common in older cats and can be tough to manage. High blood phosphorus and unstable calcium levels often make things worse. Researchers wanted to know: could adding magnesium help control these tricky minerals and slow down kidney stress? This study set out to answer that question in a safe, controlled way.

Study Details

Here’s how the research worked:

  • 31 cats with early CKD (chronic kidney disease)
  • 2 groups: magnesium supplement vs. placebo (no magnesium)
  • Double-blind setup (neither owners nor vets knew which cats got magnesium)
  • Monitored for 4 weeks
  • Blood tests tracked phosphorus, FGF-23 (a kidney stress marker), and calcium

Key Findings

Primary Results

The magnesium group saw real improvements. Cats receiving magnesium had lower blood phosphorus levels compared to those on the placebo. In numbers, the drop was significant enough that researchers noted it could make a difference for slowing kidney damage (study).

Another important marker, FGF-23—which signals kidney stress and predicts disease progression—was also lower in the magnesium group. That means the supplement seemed to ease some of the pressure on the kidneys, at least over four weeks.

For example, Sarah’s cat Milo (if he were part of the study) might see his phosphorus numbers come down and his vet feeling optimistic about the stability in his kidney health.

Secondary Findings

Calcium stayed more stable in cats on magnesium, with fewer cases of high calcium (hypercalcemia), which can be a problem in CKD. And best of all, no adverse effects were reported in the magnesium group—cats tolerated the supplement well.

However, the study was short (only one month), so we don’t know if these benefits last over time.

Implications for Pet Owners

What This Means for You

If your cat is in the early stages of CKD, magnesium supplements may help control phosphorus and protect kidney health. It’s a promising addition to a renal diet, especially if your vet is already watching those mineral levels closely.

Let’s say you decide to try magnesium (with your vet’s OK). You might notice some improvement in blood test results after about 4 weeks, just like in the study. But remember, every cat is unique—some may respond better than others.

Vet tip: Never start new supplements without checking with your veterinarian. Too much magnesium can cause problems, especially if your cat has advanced CKD or other conditions.

When to Consult Your Veterinarian

Talk to your vet before starting magnesium. It’s especially important if your cat:

  • Has moderate to severe CKD
  • Is already on other mineral supplements
  • Develops vomiting, diarrhea, or unusual lethargy

Your vet can recommend the right dose (based on your cat’s weight and lab results) and will monitor for any side effects.

Sarah, for example, keeps a diary of Milo’s appetite and energy level, and shares it with her vet at every visit.

Study Limitations

It’s important to know that this study was small (31 cats) and short (just 4 weeks). We don’t have proof that magnesium slows CKD over the long term or improves quality of life. More research is needed before magnesium becomes a standard part of CKD treatment.

Bottom Line

Magnesium supplements may help cats in the early stages of kidney disease by controlling phosphorus and reducing kidney stress markers—without major side effects. Always work with your veterinarian to see if this option fits your cat’s unique needs. With a little teamwork, you can make a real difference for your cat’s kidney health.

Quick Action Checklist

  • Ask your vet about your cat’s phosphorus, calcium, and FGF-23 levels.
  • Discuss whether magnesium supplementation is right for your cat.
  • If recommended, use only vet-approved magnesium products and follow dosing instructions (mg/kg or mg/lb).
  • Monitor your cat’s appetite, hydration, and energy weekly.
  • Schedule follow-up blood tests after 4 weeks to track progress.
  • Report any changes or side effects to your veterinarian right away.

Disclaimer

This article summarizes peer-reviewed research for educational purposes. Always consult with your veterinarian for personalized advice about your pet’s health and behavior.

Remember, with good information and a caring heart, you’re already helping your cat live their best life!

Reference

Not specified. "Magnesium Boost Eases Kidney Stress Markers in Cats". Journal of Veterinary Internal Medicine. 2025. DOI: 10.1111/jvim.17134